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Celebrating UVA Faculty Innovators on World Intellectual Property Day 2019

On World Intellectual Property Day, UVA LVG recognizes UVA faculty inventors who have earned U.S. issued patents in 2019 to date.

UVA School of Medicine faculty Brant Isakson, Boris Kovatchev, Michael Salerno, Spencer Payne, Stephen Patek, Marc Breton, Linda Columbus and William Petri, Jr., among others.

UVA School of Engineering and Applied Science faculty Haydn Wadley, Maite Brandt-Pearce, Cameron Whitehouse, Eric Loth, Mool Gupta, Xiaodong (Chris) Li, Jack W. Davidson, Jason Hiser, Benton Calhoun, George Gillies, and graduate students Zafer Vatansever, Yunya Zhang, Zan Gao, and MD Anindya Prodhan, among others.

UVA College of Arts & Sciences faculty Brooks Pate.

The innovations recognized in order of most recent are as follows:

April Patents

Method and Apparatus for Application of Metallic Alloy Coatings

U.S. Patent 10,260,143 (April 16, 2019)

Haydn Wadley

Abstract: A directed vapor deposition (DVD) method and system for applying at least one bond coating on at least one substrate for thermal barrier coating systems. To overcome the limitations incurred by conventional methods, the DVD system uses an electron beam directed vapor deposition (DVD) technique to evaporate and deposit compositionally and morphologically controlled bond coats at high rate. The present DVD system uses the combination of an electron beam and a combined inert gas/reactive gas carrier jet of controlled composition to create engineering films. In this system, the vaporized material can be entrained in the carrier gas jet and deposited onto the substrate at a high rate and with high materials utilization efficiency. The velocity and flux of the gas atoms entering the chamber, the nozzle parameters, and the operating chamber pressure can all be significantly varied, facilitating wide processing condition variation and allowing for improved control over the properties of the deposited layer.

Compositions and methods for regulating arterial tone

U.S. Patent 10,253,069 (April 9, 2019)

Brant Isakson and Linda Columbus 

Abstract: The present invention provides compositions and methods for regulating arterial tone based on the discovery herein of novel expression and regulation of hemoglobin alpha and cytochrome B5 reductase 3 and the effects on NO and NOS.

Position localization using visible light communication

U.S. Patent 10,256,906 (April 9, 2019)

Maite Brandt-Pearce and Zafer Vatansever 

Abstract: Visible-light communication (VLC) is an optical wireless communication technique that uses light emitting diodes (LEDs) or other optical sources to transmit information to a user equipment (UE) device. An optically-based location determination approach, such as using VLC infrastructure, can meet a desire for location-based services where use of VLC can provide a solution to an indoor localization or navigation problem. A fingerprinting approach can include use of an optical received signal strength (RSS) or other information (e.g., an image of a scene) to generate a spatial fingerprint map of an area. A later-received RSS on the UE device and the prior-generated fingerprint map representative of RSS can be received, and a fingerprint map and RSS observations can be provided as inputs to a Bayesian filter, such as an Extended Kalman Filter (EKF) or a Particle Filter, to provide an estimated position for the UE device.

March Patents

Smart water heater system, method and computer readable media

U.S. Patent 10,240,816 (March 26, 2019)

Kamin Whitehouse and MD Anindya Prodhan 

Abstract: A smart water heater system (SWHS) for a domestic water system having a plurality of fixtures has a water tank having a cold water inlet and a heat source configured to heat the cold water. The SWHS may also have a mixing valve to blend cold water with the hot water to produce blended water, wherein the blended water is directed to the domestic water system. The SWHS may have a controller in communication with the mixing valve configured to identify which fixture is being used when the domestic water system is drawing water from the water tank, determine an average water temperature utilized by each fixture, and adjust the mixing valve based on which fixture is identified such that a temperature of the blended water is generally equal to the average water temperature for the identified fixture.

Particle Separator

U.S. Patent 10,227,924 (March 12, 2019)

Eric Loth

Abstract: An air-inlet duct includes an outer wall, an inner wall, and a splitter. The splitter cooperates with the outer wall to establish a particle separator which separates particles entrained in an inlet flow moving through the air-inlet duct to provide a clean flow of air to a compressor section of a gas turbine engine.

Segmented chirped-pulse fourier transform spectroscopy

U.S. Patent 10,222,262 (March 5, 2019)

Brooks Pate

Abstract: An emission can be obtained from a sample in response to excitation using a specified range of excitation frequencies. Such excitation can include generating a specified chirped waveform and a specified downconversion local oscillator (LO) frequency using a digital-to-analog converter (DAC), upconverting the chirped waveform via mixing the chirped waveform with a specified upconversion LO frequency, frequency multiplying the upconverted chirped waveform to provide a chirped excitation signal for exciting the sample, receiving an emission from sample, the emission elicited at least in part by the chirped excitation signal, and downconverting the received emission via mixing the received emission with a signal based on the specified downconversion LO signal to provide a downconverted emission signal within the bandwidth of an analog-to-digital converter (ADC). The specified chirped waveform can include a first chirped waveform during a first duration, and a second chirped waveform during a second duration.

February Patents

Method of forming a spectral selective coating

U.S. Patent 10,201,947 (February 12, 2019)

Mool Gupta 

Abstract: A method of forming a spectral selective coating is disclosed. The method may include providing particles on a substrate, wherein the particles include submicron particles. The method may farther include sintering the particles under atmospheric pressure to form a sintered layer an the substrate and texturing the sintered layer to provide a submicron surface roughness height on the sintered layer.

Accuracy of continuous glucose sensors

U.S. Patent 10,194,850 (February 5, 2019)

Boris Kovatchev

A method, apparatus, and a kit are capable of improving accuracy of CGS devices using dynamic outputs of continuous glucose sensors.

Compositions and methods for treating Clostridium difficile infection

U.S. patent 10,196,453 (February 5, 2019)

William Petri, Jr.

Abstract: Clostridium difficile is the most common hospital acquired pathogen in the United States, and infection is in many cases fatal. Toxins A and B are its major virulence factors, but increasingly a third toxin may be present, known as C. difficile transferase (CDT). An ADP-ribosyltransferase that causes actin cytoskeletal disruption, CDT is typically produced by the major, hypervirulent strains and has been associated with more severe disease. It is disclosed herein that CDT enhances the virulence of two PCR-ribotype 027 strains in mice. The toxin induces pathogenic host inflammation via a novel Toll-like Receptor 2 (TLR2) dependent pathway, resulting in the suppression of a protective host eosinophilic response. Finally, it is disclosed that restoration of TLR2 deficient eosinophils is sufficient for protection from a strain producing CDT. These findings offer an explanation for the enhanced virulence of CDT-expressing C. difficile and demonstrate a mechanism by which this binary toxin subverts the host immune response.

Process of forming electrodes and products thereof from biomass

U.S. Patent 10,199,178 (February 5, 2019)

Xiaodong (Chris) Li, Yunya Zhang, and Zan Gao 

Abstract: A flexible electrode comprises an activated cotton textile composite comprising activated carbon fibers, nickel sulfide nanoparticles and graphene and a process for making the flexible electrode. The process may comprise preparing a cotton textile containing Ni(NO3)2. Then, the cotton textile containing Ni(NO3)may be heated at a first temperature to produce an activated cotton textile composite comprising activated carbon fibers, nickel nanoparticles and graphene. The activated cotton textile composite may be then treated with sulfur to produce an activated cotton textile composite comprising activated carbon fibers, nickel sulfide nanoparticles and graphene. The nickel sulfide particles may be NiSnanoparticles in a form of nanobowls, and distributed on a surface and inside the activated carbon fibers. The activated carbon fibers and the nickel sulfide nanoparticles may be coated with graphene. Banana peels may be activated and treated with the similar processes to form electrodes for both supercapacitor and battery applications.

Free-breathing parameter mapping with high-contrast image registration

U.S. Patent 10,198,810 (February 5, 2019)

Michael Salerno 

Abstract: In one aspect, the disclosed technology relates to a method which, in one example embodiment, includes acquiring magnetic resonance imaging data for a plurality of images of the heart of a subject during free breathing of the subject. The method also includes generating an additional plurality of images with high tissue-blood contrast over the region of interest, and selecting a subset of images from the plurality of images, based upon a pre-determined quality metric of image similarity, to be used for non-rigid image registration. The method also includes aligning the subset of images by non-rigid image registration using a combination of the plurality of images and the additional plurality of images, and creating a parametric map from the aligned images.

January Patents 

Lightweight ballistic resistant anti-intrusion systems and related methods thereof

U.S. Patent 10,184,759 (January 22, 2019)

Haydn Wadley

Abstract: A method for manufacturing a ballistic resistance package which includes providing a molecularly oriented tape material having a front face and back face with a minimum of two sets of parallel side faces; wrapping molecularly oriented fabric material around the front and back faces and a set of the parallel side faces of the molecularly oriented tape material, yielding a wrapped core structure; and finalizing the wrapped core structure to yield the ballistic resistance package. A multifunction ballistic resistance system for resisting projectiles and/or mitigating blast effects of explosions. The multifunction ballistic resistance system may include: at least one cellular frame defining cells therein, and a plurality of molecularly oriented tape material core structures wrapped in molecularly oriented fabric material and finalized, and attached to at least one cellular frame.

Method of instruction location randomization (ILR) and related system

U.S. Patent 10,193,927 (January 29, 2019)

Jack W. Davidson, Jason D. Hiser, Anh Nguyen-Tuong, Michele Co 

Abstract: Systems and methods for relocating executable instructions to arbitrary locations are described, in which the relocation of the instructions may be arbitrary or random, and may operate on groups of instructions or individual instructions. Such relocation may be achieved through hardware or software, and may use a virtual machine, software dynamic translators, interpreters, or emulators. Instruction relocation may use or produce a specification governing how to relocate the desired instructions. Randomizing the location of instructions provides defenses against a variety of security attacks. Such systems and methods may provide many advantages over other instruction relocation techniques, such as low runtime overhead, no required user interaction, applicability post-deployment, and the ability to operate on arbitrary executable programs.

Devices and methods for protecting an internal channel of a subject

U.S. Patent 10,172,639 (January 8, 2019)

Spencer Payne

Abstract: Devices and methods for protecting an internal channel of a subject are disclosed. In one example embodiment, a device for protecting an internal channel of a subject includes a first end portion having a first diameter and defining a first opening, and a second end portion opposite the first end portion having a second diameter and defining a second opening that is in communication with the first opening. A body portion is defined between the first end portion and second end portion. The body portion defines an interior passage between the first opening and second opening, and is expandable along a longitudinal axis from a collapsed state to an expanded state.

LQG artificial pancreas control system and related method

U.S. Patent 10,173,006 (January 8, 2019)

Stephen Patek, Marc Breton

Abstract: The invention relates to a methods and systems for determining an insulin dosing recommendation. The invention employs Linear Quadratic methodology to determine the insulin dosing recommendation based on a patient's present physiological state, which is estimated by an adaptive filter methodology employing a dynamic model, which utilizes real-time measurements of blood glucose concentration.

System, method and computer program product for protecting software via continuous anti-tampering and obfuscation transforms

U.S. Patent 10,176,324 (January 8, 2019)

Jack Davidson, Jason Hiser 

Abstract: Method, system and computer program product for applying existing anti-tampering and obfuscation techniques to virtual machine technology and offers several distinct advantages. The anti-tampering and obfuscation transforms can be applied continuously to prevent adversaries from gaining information about the program through emulation or dynamic analysis. In addition, the encryption can be used to prevent hackers from gaining information using static attacks. The use of a virtual machine also allows for low overhead execution of the obfuscated binaries as well as finer adjustment of the amount of overhead that can be tolerated. In addition, more protection can be applied to specific portions of the application that can tolerate slowdown. The in-corporation of a virtual machine also makes it easy to extend the technology to integrate new developments and resistance mechanisms, leading to less development time, increased savings, and quicker deployment.

Methods and apparatus for a single inductor multiple output (SIMO) DC-DC converter circuit

U.S. Patent 10,170,990 (January 1, 2019)

Benton Calhoun 

Abstract: In some embodiments, an apparatus includes a single-inductor multiple-output (SIMO) direct current (DC-DC) converter circuit, with the SIMO DC-DC converter circuit having a set of output nodes. The apparatus also includes a panoptic dynamic voltage scaling (PDVS) circuit operatively coupled to the SIMO DC-DC converter circuit, where the PDVS circuit has a set of operational blocks with each operational block from the set of operational blocks drawing power from one supply voltage rail from a set of supply voltage rails. Additionally, each output node from the set of output nodes is uniquely associated with a supply voltage rail from the set of supply voltage rails.

Simulation of endogenous and exogenous glucose/insulin/glucagon interplay in type 1 diabetic patients

U.S. patent 10,169,544 (January 1, 2019)

Marc D. Breton and Boris P. Kovatchev

Abstract: A simulator for in-silico testing of Type 1 diabetes patients uses a model that puts in relation plasma concentrations, i.e., glucose G and insulin /, with glucose fluxes, i.e. endogenous glucose production (EGP), glucose rate of appearance (Ra), glucose utilization by the tissues (U), renal extraction (E), and insulin fluxes, i.e., rate of insulin appearance from the subcutaneous tissues (SC) and insulin degradation (D). A module is also included to describe counter-regulation, i.e. glucagon kinetics, secretion and action. A glucagon subcutaneous absorption model enables simulation of dual hormone control.

Epicardial ablation catheter and method of use

U.S. patent 10,166,066 (January 1, 2019)

George Gillies

Abstract: An aspect of various embodiments of the present invention system and method provide, but not limited thereto, a novel means for epicardial ablation using a double-curve steerable sheath and a double-curve deflectable open irrigated-tip/suction catheter that can be guided around the apex of the heart and adjusted so as to position the distal tip optimally. The catheter can also both deliver fluid to and withdraw fluid from the pericardial space. Access to the epicardial surface of the heart is via a subxiphoid entry. The method and means presented include, but are not limited to, steering, energy delivery, bipolar mapping, placement and use of electrodes, irrigation, suction of irrigation fluid, and other details of the subject invention.