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August 2019 U.S. Issued Patents

Innovations in bone surface imaging using ultrasound, computer engineering, the treatment of dry-eye disease, and more 

UVA faculty Timothy MacdonaldDoris HaverstickJohn HossackJack DavidsonHaydn Wadley, and Gordon Laurie are among the inventors issued U.S. patents in August 2019. 

August Patents

T Type Calcium Channel Inhibitors

U.S. Patent 10,369,120 (Aug. 6, 2019)

Lloyd Gray, Timothy Macdonald, Doris Haverstick

Abstract: The present invention provides novel T type calcium channel inhibitors of formula (I), the use thereof in the treatment of a disease or condition in a mammal associated with influx of extracellular calcium via T type calcium channels, wherein R1 is C1-C4 alkyl, hydroxy, or C1-C4 alkoxy; Z is NH, NCH3, O, S, or CH2; Y is NH, O, or CH2 with the proviso that Y and Z are not the same; R2 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy; m and n are independently selected from integers ranging from 1-5 with the proviso that m+n=an integer ranging from 2-9; and R3 is H, halo, NH2, C1-C4 alkyl, hydroxy, or C1-C4 alkoxy.

Bone Surface Image Reconstruction Using Ultrasound

U.S. Patent 10,368,834 (Aug. 6, 2019)

William F. Mauldin Jr., John Hossack, Kevin Owen

Abstract: An ultrasonic transducer element can configured to generate ultrasonic energy directed into tissue of a subject and configured to receive a portion of the ultrasonic energy reflected by a target located within the tissue. The ultrasonic transducer can include a surface configured to provide or receive the ultrasonic energy, the surface including an area of greater than or equal to about 4λ2, or the ultrasonic transducer element can be included in an array having a spacing between at least two adjacent ultrasound elements of less than or equal to about 1/2 λ, and the array comprising an aperture that is at least approximately symmetrical in two axes. A three-dimensional representation of one or more of a location, shape, or orientation of at least a portion of the target can be presented via the display.

Methods, Systems and Computer Readable Media for Detecting Command Injection Attacks 

U.S. Patent 10,382,448 (Aug. 13, 2019)

Anh Nguyen-Tuong, Jack Davidson, Michele Co, Jason Hiser, John Knight (deceased)

Abstract: Methods and systems are described for detecting command injection attacks. A positive, taint inference method includes receiving signature fragments on one hand, converting command injection instructions into command fragments on another hand, thus identifying potential attacks upon the condition that a command injection instruction includes critical untrusted parts by using signature fragments. A system detects command injection attacks using this kind of method, and remediates and rejects potential attacks.

Impulse Mitigation Systems for Media Impacts and Related Methods Thereof

U.S. Patent 10,378,861 (Aug. 13, 2019)

Haydn Wadley, Vikram Deshpande (U of Cambridge) 

Abstract: An impulse mitigation system configured to mitigate blast impulse directed to a surface (or structure or target). The system includes a substrate in communication with the surface (or structure or target), wherein the substrate is configured to receive an impulse directed to the surface (or structureor target) and then relocate from the surface (or structure or target) in response to received impulse.

Compositions and Methods for Treating Eye Infections and Disease 

U.S. Patent 10,393,755 (Aug. 27, 2019)

Gordon Laurie

Abstract: The present invention provides compositions and methods for identifying subjects suffering from dry eye that can be treated by topical administration of a composition comprising lacritin or a bioactive fragment thereof. The application discloses in part that a ~90 KDa deglycanated form of syndecan-1 is abundant in tears of normal individuals but not individuals suffering from dry eye, whereas a ~25 kDa syndecan-1 fragment is detectable in dry, but not normal tears.